Lansoprazole

Lansoprazole

Lansoprazole: is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid. It is manufactured by a number of companies worldwide under several brand names (some brand names include: Prevacid, Helicid, Zoton, Inhibitol, Monolitum). It was first approved by the U.S. Food and Drug Administration (FDA) in 1995^.

Lansoprazole is a proton-pump inhibitor (PPI) in the same pharmacologic class as omeprazole. Lansoprazole has been marketed for many years and is one of several PPIs available. Lansoprazole is a racemate [1:1-mixture of the enantiomers dexlansoprazole (Kapidex) and levolansoprazole]. Dexlanprantazole is an enantiomerically pure active ingredient of a commercial drug as a result of the 'enantiomeric shift'.

Side effects

·                    Infrequent: dry mouth, insomnia, drowsiness, blurred vision, rash, pruritus

·                    Rarely and very rarely: taste disturbance, liver dysfunction, peripheral oedema, hypersensitivity reactions (including bronchospasm, urinary, angioedema, anaphylaxis), photosensitivity, fever, sweating, depression, interstitial nephritis, blood disorders (including leukopenia, leukocytosis, pancytopenia, thrombocytopenia), arthralgia, myalgia, skin reactions including (erythroderma Stevens–Johnson syndrome, toxic epidermal necrolysis, bullous eruption)

·                    Severe: Gastro-intestinal disturbances (such as nausea 1.3%, abdominal pain 2.1%, diarrhea 3.8%).

Proton-pump inhibitors may be associated with a greater risk of hip fractures, Clostridium difficile-associated diarrhea. Patients are frequently administered the drugs in intensive care as a protective measure against ulcers, but this use is also associated with a 30% increase in occurrence of pneumonia.



The drug is sold under several brand names, including:
Brand names

·                    Agopton (Germany)

·                    Digest (Indonesia)

·                    Duogast (Syria)

·                    Gastrolan (Indonesia)

·                    Lanciprol (Greece)

·                    Lansazol (Jordan)

·                    Lansobene (Austria)

·                    Lansoloc (South Africa)

·                    Lansoprazol (Denmark)

·                    Lansoptol (Hungary)

·                    Lansor (Turkey)

·                    Lansox (Italy)

·                    Lanston LFDT (South Korea)

·                    Lenzo (India)

·                    Lanzol (India, Ireland)

·                    Lanzotec (Jordan)

·                    Lanzul (Slovenia)

·                    Lanton (Israel)

·                    Lanzo (Sweden)

·                    Lanzor (France, South Africa)

·                    Lanzostad (Lithuania, Latvia, Estonia)

·                    Laprazol (Greece)

·                    Limpidex (Italy)

·                    Monolitum (Spain)

·                    Ogast and OgastORO (France)

·                    Ogastro (Mexico)

·                    Prevacid (U.S. and Canada)

·                    Prosogan and Prosogan FD (Indonesia)

·                    pro-ulco (Spain)

·                    Refluxon (Hungary)

·                    Sabax (Serbia)

·                    SOLOX (New Zealand)

·                    Takepron (Japan)

·                    Zolt (Finland)